Identification of Factors Predicting Diabetes Insipidus Occurrence Following Endoscopic Trans-Sphenoidal Surgery for Pituitary Adenoma in Developing Country

Agung Budi Sutiono^1,2*, Roland Sidabutar¹, Ingrid Ayke Wijaya¹, Yulius Hermanto¹, Ryo Ueda² & Masahiro Toda²

¹Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia
²Department of Neurosurgery, Keio University Hospital School of Medicine, Tokyo, Japan

Dr. Agung Budi Sutiono, Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia & Keio University Hospital School of Medicine, Tokyo, Japan.

Keywords: Predicting Factors; Transient Diabetes Insipidus; Pituitary Adenoma; Endoscopic Trans-Sphenoidal Surgery

Abstract

Introduction
Transient diabetes insipidus (DI) is a common problem following endoscopic transphenoidal surgery of pituitary adenoma. Delayed intervention may lead to increased morbidity, and prolonged hospitalization. Predicting which patients are at higher risk for developing transient DI can improve medical services to ensure adequate care.
Methods
We retrospectively performed a cross sectional study to identify which variables are associated with transient DI at our department during March 1, 2018 - May 31, 2020.
Results
From 51 patients, transient DI was observed in 26 of 51 patients (50.98%). Upon bivariate analysis, we found 4 variables that potentially become predictors for transient DI occurrence: visual field disturbance (p=0.0238), hormonal disturbance (p=0.0109), larger tumor (>2.8cm) (p=<0 p=0.0008).>

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