Comparative Study of Oxytocin on Hemodynamic Parameters in Variceal Upper Gastrointestinal Bleeding in Antananarivo

Rahanitriniaina, N. M. P.¹, Rakotondrainibe, A.^1*, Raelison, J. G.², Rakotondrabe, A.¹, Randriamizao, H. M. R.¹ & Rajaonera, A. T.¹

¹Service de Réanimation Chirurgicale CHU Joseph Ravoahangy Andrianavalona Antananarivo, Madagascar
²Service accueil triage urgence CHU Joseph Raseta Befelatanana Antananarivo Faculté de Médecine d’Antananarivo, Université d’Antananarivo, Madagascar

Dr. Rakotondrainibe Aurelia, Department, University of Antananarivo, Madagascar.

Keywords: Esophageal Varices; Hemorrhage; Madagascar; Oxytocin; Upper Gastrointestinal Tract

Abstract

Introduction
Variceal upper gastrointestinal bleeding remains a common pathology, particularly in Madagascar, because of its schistosomiasis and cirrhotic etiology. It remains an important cause of morbidity and mortality, especially since the vasoactive treatment or the band ligation are not performed early. In Madagascar, vasoactive drugs (octreotide, somatostatin, terlipressin) are unavailable. In the Surgical Intensive Care Unit of the JR Andrianavalona University Hospital Center (CHU JRA), before 2015, oxytocin was used as an “alternative” for vasoactive treatment. The aim of this study was to assess the effect of oxytocin on hemodynamic parameters and to compare them according to the use or not use of oxytocin in variceal upper gastrointestinal bleeding.
Method
Case - control study was performed in the Surgical Intensive Care Unit of CHU JRA over eight years (from 2010 to 2017). The study population was divided into two groups: O+ Group (use of oxytocin, from 2010 to 2014) and O- Group (no use of oxytocin, from 2015 to 2017). The demographic, hemodynamic parameters of patients with variceal upper gastrointestinal bleeding were studied. The comparison (Mann Whitney test) of the hemodynamic parameters according to the use of oxytocin between the two groups and the correlations (Pearson’s test) between the use of oxytocin and the hemodynamic parameters as well as the mortality were analyzed  (SIGMASTAT^® 3.5).

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).