The Effect of Androgen Deprivation Therapy on Voice Quality in Patients Having Localized Prostate Cancer

Alsan Cetin Ilknur^1* & Dogan Muzeyyen²

¹Department of Radiation Oncology, Marmara University Faculty of Medicine, Turkey
²Department of ENT, Yeditepe University Faculty of Medicine, Turkey

Dr. Alsan Cetin Ilknur, Department of Radiation Oncology, Marmara University Faculty of Medicine, Turkey.

Keywords: Prostate Cancer; Androgen Deprivation Treatment; Acoustic Analysis

Abstract

Objective
To evaluate the voice quality in patients having localized prostate cancer, who were treated with radiotherapy and androgen deprivation therapy, by subjective and objective methods.
Material and Methods
Sixteen patients having localized prostate cancer, were included in the study. Before androgen deprivation therapy, baseline acoustic analyses were performed by the Multi-Dimensional Voice Program (MDVP; Kay Elemetrics Corporation, Lincoln Park, NJ) and the movements of the vocal cords were examined by videolaryngostroboscopy (VLS). Maximum phonation time was examined and Voice Handicap Index (VHI) is used for subjective evaluations. Baseline total testosterone levels are also recorded. Follow-up visits were planned on the first, the third and the sixth month of the treatment. Androgen deprivation therapy, which is used as a supplementary method to radiotherapy, includes a LHRH analogue and anti-androgen. One sample t test was used for the difference between the fundamental frequency values. Paired-sample T test was used to compare the maximum frequency times with 3 audio analyzes. p<0.05 value was considered for statistical significance.

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