Immunopathogenesis of Autoimmune Diseases

Sanam Dolati

Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Dr. Sanam Dolati, Department of Immunology, Faculty of Medicine, TabrizUniversity of Medical Sciences, Tabriz, Iran.

Keywords: Autoimmunity; Immunological Tolerance; Autoantibodies

Abstract

Autoimmunity is arisen by numerous coextensive mechanisms that are in connection with the existence of auto-reactive immune cell subsets and defeat of immunological tolerance. Autoimmune diseases affect more than 3% of the world population, amongst which 80% are women. Autoimmune diseases are categorized by abnormal immune responses against ealthy cells and tissues. Nevertheless, the particular pathogenesis of autoimmune disease remains vague. In this study, I review pathogenesis of autoimmune diseases, such as SLE, RA, MS and T1DM, which are categorized by the existence of autoreactive immune cells or the progress of particular autoantibodies.

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