Sulfonamides: A Promising Pharmacophore as Carbonic Anhydrase Inhibitor

Mahmood Ahmed

Institute of Chemistry, University of the Punjab, Renacon Pharma Limited, Lahore-Pakistan

Mahmood Ahmed, Institute of Chemistry, University of the Punjab, Renacon Pharma Limited, Lahore-Pakistan.

Keywords: Pharmacophore; Enzymes; Homeostasis; Neurotransmission

Abstract

Sulfonamides are important pharmacophores which are extensively employed as antifolic agent by acting as competitive inhibitors of dihydropteroate synthase enzyme. These are structurally similar to p-aminobenzoic acid (PABA) which is cofactor for synthesis of folic acid by bacteria. So as an analog of PABA, sulphonamides can compete with it efficiently to prevent synthesis of proteins and nucleic acid which result the inhibition of various microorganisms.

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