Diabetes Neuropathic Pain: Therapeutic Agents for the Ailment and Analytical Methods for the Measurement of Their Biological Fluids Concentrations

Chika Mbah, J.

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

Dr. Chika Mbah, J., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

Keywords: Diabetes Neuropathic Pain; Therapeutic Agents; Biological Fluids; Analytical Methods

Abstract

Diabetic neuropathy consists mainly of two types namely, sensorimotor and autonomic neuropathy respectvely. Pain, paraesthesia and sensory loss are common features of sensorimotor neuropathy while malignant arrhythmia, myocardial infarction and sudden death are associated with autonomic neuropathy. The aim of the study was to provide analytical methods employed to measure therapeutic agents utilized in the treatment of diabetes neuropathic pain in biological fluids. The methodology involved obtaining relevant information from scientific journals, reference books in libraries and internet websites. The results indicate that treatment of the ailment mostly involve the use of antiepileptic agents, antidepressants, antihypertensive agents, opioid analgesic agents. Gas or liquid chromatographic methods (hyphenated and non-hyphenated) electrochemical, electrophoresis and spectroscopic methods were found to be the analytical methods used to measure therapeutic agents for diabetes neuropathic pain in biological fluids. Of all these analytical methods, high performance liquid chromatography (liquid chromatographic method) seems to be the analytical method of interest.

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