Chemical and Biological Characterization of Newly Synthesized Drug Based Metal Complexes

Amina Mumtaz^1,2*, Tariq Mahmud², Weaver, G. W.³ & Elsegood, M. R. J.³

¹PCSIR Laboratories Complex, Ferozepur Road, Lahore-Pakistan
²Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan
³Department of Chemistry, Loughborough University, Loughborough, LE11 3TU, England

Amina Mumtaz, Department of Chemistry, PCSIR Laboratories complex, Ferozepur Road, Lahore, Pakistan.

Keywords: Schiff Base; Metal Complex; Sulphadoxine; 2-Hydoxybenzaldehyde; Antimicrbial

Abstract

The wide utilization of the anti-infection agents brought about the serious therapeutic issue of medication protection and general wellbeing concern. Synthesis of new antibiotics having more antibacterial activity has turned into an imperative errand to adapt to tranquilize protection issues. For this purpose, Synthesis of novel Schiff base ligand was done with a series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes. The ligand and metal complexes were the characterized by using different instruments like FT-IR, ¹H NMR, ¹³C NMR, Mass, Atomic absorption spectroscopy, Elemental analyzer, UV-visible Spectrophotometer, Evans balance and Conductivity meter. The synthesized ligand and transition metal complexes were tested against various bacteria and fungi. These studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free Schiff base ligand.

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